Diabetic peripheral neuropathy - the prevalence and potential risk factors in type 2 diabetes mellitus

Kampen, W. van (Willeke) (2015) Diabetic peripheral neuropathy - the prevalence and potential risk factors in type 2 diabetes mellitus. thesis, Medicine.

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Abstract

Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of type 2 diabetes mellitus (T2DM) worldwide. It can be accompanied by debilitating pain, often leads to impaired mobility and is strongly associated with the development of ulcers and necessity of non-traumatic limb amputations. As no curative treatments are available, it is important that patients at risk are identified early and preventive strategies are optimized. However, much remains unclear concerning epidemiological features, the pathogenesis and the risk factors for DPN. Objective: The aim of this study was to investigate the prevalence of DPN in patients with T2DM in a secondary care setting in the Netherlands and to identify potential risk factors for DPN. Patients and Methods: In this cross-sectional cohort study 358 patients with T2DM were included. All attended the outpatient clinic of internal medicine for their diabetes management. Data were collected through questionnaires, physical examination and analyses of blood- and urine samples. The presence of DPN was determined using the results of the most recent foot examination prior to the study visit (< 1 year). Associations between potential risk factors and DPN were assessed by multivariate logistic regression analysis. Results: The prevalence of DPN in secondary care T2DM patients was 35%. The final predictive model for DPN included 7 independent variables. The 3 variables with the highest odds ratio were: female sex (OR 2.71), the presence of nephropathy (OR 2.34) and the presence of peripheral artery disease (OR 2.92). Conclusion: The high prevalence of DPN in a hospital care setting implicates the need for awareness from clinicians. Aside from the well-established risk factors for DPN, like glycemic control and age, multiple other determinants might help to identify patients at risk of DPN.

Item Type:	Thesis (Thesis)
Supervisor name:	Begeleider: and Laverman, dr. G.D. and Locatie: ZGT Almelo - afdeling interne geneeskunde
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:58
Last Modified:	25 Jun 2020 10:58
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1869

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