Vries, L. (Liza) de (2012) COPD en lichamelijke activiteit. thesis, Medicine.
Full text available on request.Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality with increasing prevalence. The most striking feature in COPD is the presence of chronic airway obstruction that is slowly progressive and largely irreversible. The main symptoms are breathlessness, cough and increased sputum production. The current gold standard for diagnosis and treatment focuses on the presence of pulmonary symptoms and the measurement of lung function (FEV1%). There is no strong correlation between FEV1% and the level of complaints experienced by patients. The health status, which can be measured with the Clinical COPD Questionnaire (CCQ), reflects the influence of disease on functional status, symptoms and mental state of the patient. The functional status is an important component of health status. The tests which give a good impression of the functional status of the patient are the six minute walk test (6MW) and a measurement of quadriceps strength. The student examines the correlations between functional status, FEV1%, the Clinical COPD Questionnaire and the individual domains. The student also examines which independent variables contribute to the 6MW and quadriceps strength scores using multivariate linear regression analysis. The included COPD patients (n = 37) answered the Clinical COPD Questionnaire, performed a lung function test and performed the 6MW and quadriceps strength measurement during one visit. Significant correlations were found between the 6MW and the functional domain of the CCQ, between the 6MW and the FEV1% and between the CCQ total score and FEV1%. The correlation found between the functional domain of the CCQ and the 6MW is less strong than expected (-0.384 p = 0.019). A similar correlation was found between FEV1% and 6MW. The correlation found between the CCQ and lung function (FEV1%) corresponds to correlations from previous research, -0.512 (p = 0.001). Stepwise multivariate analysis shows that the functional domain of the CCQ and the educational level of the patient are significant covariates in the model for the 6MW. Gender and age are the contributing covariates in the multivariate regression model for quadriceps strength. The results show that both lung function (FEV1%) and the functional domain correlate with the 6MW. It appears that the lung function is not a contributing covariate in the regression model for the 6MW or the quadriceps strength, totally different covariates seem to be important. That the regression models of the 6MQ en quadriceps strength are so different from each other is remarkable. In short, these findings support the hypothesis that not only FEV1% is important in the functional status of COPD patients; it might be useful to determine how other factors influence the functional state of patients with COPD.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Jong, Drs C. de and Oosterom, W. and Disciplinegroep huisartsgeneeskunde and Universitair Medisch Centrum Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:58 |
| Last Modified: | 25 Jun 2020 10:58 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1846 |
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