Lebbink, M.A. (2017) Daily symptomatology and microbiome-related risk factors in children with recurrent respiratory infections. thesis, Medicine.
Full text available on request.Abstract
Background Recurrent respiratory infections in children are a therapeutic challenge for the paediatrician. The daily symptomatology is unclear and the pathology not completely understood. Knowing the symptomatology and risk factors could lead to pathologic insight and new therapeutic opportunities. In this study we hypothesize the microbiome plays a role in the pathology. We give an impression of the daily symptoms and determine microbiome-related risk factors. Methods A matched case-control study was conducted in a secondary children’s hospital in the Netherlands. Information about birth moment, delivery mode, breastfeeding, pet exposure and siblings was obtained through questionnaires from cases (n = 67) and controls (n = 165). These microbiome-related risk factors were analysed by univariate and multivariable conditional logistic regression. For a subset of cases daily symptoms during fall and winter season were recorded by the parents in a mobile application diary. Results A median of 76 days with respiratory symptoms per 100 days was found. Symptoms with highest frequency were rhinorrhea (52 days per 100 days) and coughing (40 days per 100 days). A median of 1,5 respiratory infection per 30 days was found. One episode had a median duration of 8 days and the periods between episodes had a median duration of 4 days. The factor breastfeeding (≥6 months breastfeeding vs never breastfeeding OR 0,03; P 0,00) showed a remarkable significant association in multivariable analysis. Against the hypothesis also for caesarean section an association was found (OR 0,11; P 0,02). For preterm birth, pet exposure and siblings no association was found. Conclusions The daily burden of disease in children with recurrent respiratory infections is high during fall- and winter season. Core symptoms are rhinorrhea and coughing. A longer duration of breastfeeding and a caesarean section had a negative association with recurrent respiratory infections. To demonstrate a causal relation between the microbiome and recurrent respiratory infections further research is necessary.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisors: and Verhagen, dr. L.M. and and and Huugen, dr. D. and Pediatric Infectious Diseases and Immunology, Wilhelmina Chi |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/183 |
Actions (login required)
 |
View Item |