Nijboer, R. (Roos) (2017) Adherence to statins in high risk type 2 diabetes mellitus patients seems adequate: is it still necessary to pay attention to adherence? thesis, Medicine.
Full text available on request.Abstract
Background: Adherence is important but often neglected in diabetes mellitus type 2 (T2DM). Lowering low-density lipoprotein cholesterol (LDL-cholesterol) with statins reduces the risk of developing cardiovascular disease (CVD). Non-adherence to statins is associated with a greater risk of developing complications. Currently, little is known about the degree of statin non-adherence in T2DM in the second line. Aim: We aim to investigate the percentage of patients with T2DM that is non-adherent to statins, followed in a Dutch secondary health care centre. Materials and Method: In this cross-sectional cohort study, 157 patients with T2DM were included. Adherence was measured by the Medication Possession Ratio (MPR). The following definition for adherence was used: ≥ 80% of the prescribed medication was obtained from the pharmacy. Results: In 119 patients a statin was prescribed. The median age was 64 (60-69) years, and there were more men (57%). 11% of the patients were non-adherent to statins. This group had a significant higher median LDL-cholesterol than adherent patients (2.2 (1.8-2.9) mmol/L vs. 1.7 (1.3-2.2) mmol/L, p = 0.01). There was a trend toward non-adherent patients less often reaching the LDL-cholesterol target of ≤ 2.5 mmol/L than the adherent group (67% vs. 85%, p = 0.1). Conclusion: Adherence to statins in patients with T2DM treated in the secondary health care centre seems adequate. It is important to pay attention to the non-adherent group, as they achieve the LDL-cholesterol target less often. Future research will extend our findings with direct and objective measurements of therapy adherence, to account for the limitations of the MPR method.
| Item Type: | Thesis (Thesis) |
|---|---|
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:58 |
| Last Modified: | 25 Jun 2020 10:58 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1828 |
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