Doldersum, E. (2018) Corticomuscular and intermuscular coherence as a biomarker of pallidal Deep Brain Stimulation efficacy in dystonia. thesis, Medicine.
Full text available on request.Abstract
Background: Dystonia is a group of hyperkinetic movement disorders that are characterized by an abnormal muscle tone. Deep Brain Stimulation (DBS) is a therapy that has been proven effective and safe in dystonia. However, a wide variety exists in the effect of DBS in dystonia patients and the effect of DBS cannot be predicted. A reliable biomarker for the efficacy of DBS does not exists at the moment, but could be useful for patient care. Therefore, the aim of this study was to find a possible biomarker that could indicate the efficacy of DBS in dystonia patients. Method: In this explorative, prospective pilot study, 12 dystonia patients receiving DBS were included. Corticomuscular coherence (CMC) between electroencephalography (EEG) and electromyography (EMG) was calculated, as well as intermuscular coherence (IMC) between EMG and EMG, during a rest condition, a pinch task, and a flexion task. This was done before DBS surgery, and after DBS surgery both on and off stimulation. Clinical assessments were performed with use of the Burke Fahn Marsden Dystonia Rating Scale (BFMDRS) and the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Differences in coherences with and without DBS were tested with the Friedman test. Correlations were tested with the Spearman’s test for the relations between coherences and the clinical assessments. Results: This study showed that DBS could significantly reduce coherences. For both CMC and IMC analyses, decreases in coherences have been observed with DBS. Significant correlations were found between the coherences and the clinical assessment scores, but only a few could be used to indicate the efficacy of DBS. Conclusion: The results of this study show promising possibilities for coherence as a biomarker for DBS efficacy in dystonia patients, but more extensive research needs to be conducted to validate these results in larger patient populations in order to define reliable biomarkers.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor and Koning-Tijssen, Prof. dr. M.A.J. deNeurologist and Second supervisor and Zijl, Drs. J.C. van and Other supervisor and Elting, Dr. J.W.J. Neurologist and Clinical Neurophysiologis and Department of Neurology, University Medical Centre Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:57 |
| Last Modified: | 25 Jun 2020 10:57 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1797 |
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