Assessment of Diagnostic Accuracy of Dynamic Contrast-Enhanced Ultrasound and Multiparametric MRI Techniques By Comparing Imaging With Radical Prostatectomy Specimens.

Postema, A. (Arnoud) (2013) Assessment of Diagnostic Accuracy of Dynamic Contrast-Enhanced Ultrasound and Multiparametric MRI Techniques By Comparing Imaging With Radical Prostatectomy Specimens. thesis, Medicine.

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Abstract

Purpose: To evaluate the accuracy of Dynamic Contrast-Enhanced UltraSound imaging (DCE-US) in comparison with multiparametric Magnetic Resonance Imaging (mpMRI) for the detection of prostate cancer, using whole mount radical prostatectomy specimens as reference standard. Materials and Method: For this exploratory cohort study, thirty-eight patients were included with biopsy-proven prostate cancer, that underwent both DCE-US and mpMRI imaging procedures before radical prostatectomy. Two observers for both imaging modalities performed interpretation. The presence of suspicious nodules on imaging was recorded for each of the standardized regions of interest(ROI) and correlated with pathological findings using various methods of correlation. Sensitivity and specificity were determined for each of the imaging observers. The extended McNemar’s test was used to analyse differences in the diagnostic performance between the observers. Results: Between 284 and 316 ROI’s were included in the different analyses. In the most liberal correlation between imaging and pathology the DCE-US observers attained sensitivities of 41-59% with a specificity of 82-87%. The mpMRI results under the same conditions varied between 44-45% for sensitivity and 90-93% for specificity. Under less liberal conditions the first DCE-US observer attained a sensitivity of 46%, which was significantly better than all other observers ranging between 29-33%. Although one of the mpMRI observers reached significantly higher specificity under those same conditions, 89% versus 74%. Conclusion: MpMRI performance in our study is lower than generally reported and the performance of DCE-US varies markedly between observers. Our results show that, under the same conditions, DCE-US imaging can achieve a higher sensitivity than mpMRI imaging. With mpMRI imaging it is possible to achieve a higher specificity.

Item Type:	Thesis (Thesis)
Supervisor name:	Karthaus, Dr. A.J.M.
Supervisor name:	Reijke, Dr. Th.M. De and AMC, Urologie
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:57
Last Modified:	25 Jun 2020 10:57
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1751

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