Hoeksma, E. (Eva) (2019) One night of partial sleep restriction affects glucose and lipid metabolism : A randomized cross-over study on the effect of one night of partial sleep restriction on glucose and lipid metabolism in healthy men. thesis, Medicine.
Full text available on request.Abstract
Rationale: Sleep restriction is associated with obesity and type 2 diabetes, suggesting that insufficient sleep might impair metabolic pathways. Previously, the effects of severe sleep restriction on fasting blood samples have been examined in lean individuals. Therefore, this study was undertaken to investigate the effect of one night of partial sleep restriction on fasting and postprandial glucose metabolism and lipid metabolism in both lean and obese individuals. Methods: This randomized crossover trial studied 31 healthy males, with a BMI ranging from 20 to 35 kg/m2, after one night of 4 hours of sleep (SS) and after one night of 8 hours of sleep (NS). Glucose, insulin, free fatty acids (FFA), triglycerides (TG) and phospholipids (PL) were measured fasting and 30, 60, 90, 120, 180 and 240 minutes after a morning (M) and after an afternoon (A) standardized meal and compared between SS and NS with a paired t-test or Wilcoxon signed rank test. Results: Fasting FFAs increased after SS (NS: 0,34 mmol/L (IQR 0,26 – 0,38); SS: 0,47 mmol/L (IQR 0,38 – 0,70); p = 0,00). Sleep restriction delayed the morning postprandial glucose peak from 30 minutes (NS: 6,32 mmol/L ± 1,35; SS: 5,76 mmol/L ± 1,00; p = 0,040) to 60 minutes (NS: 5,50 mmol/L (IQR 4,75-6,26); SS: 6,20 mmol/L (IQR 5,16-7,39); p = 0,030). TG-levels were not altered after SS. Sleep restriction tended to decrease PL-levels (M: NS: 636,83 ± 88,50; SS 608,00 ± 77,25 (p = 0,092); A: NS: 708,45 (IQR 559,80-747,60); SS: 664,05 (IQR 572,55726,15) (p = 0,128)), since all time points but 90, 120 and 180 minutes are significant. Conclusion: One night of partial sleep restriction reduces insulin sensitivity and seems to alter lipid metabolism. The influence of body composition was minimal. These observations may be of relevance for preventing and treating type 2 diabetes and obesity.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor and Mijnhout Dr. G.S. Isala Clinics Zwolle, department of Intern |
| Supervisor name: | Supervisors and Pelsma, Drs. I.C.M. M.D. PhD researcher and Biermasz Prof. dr. N.R. and Leiden University Medical Center, department of Endocrinolog |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:57 |
| Last Modified: | 25 Jun 2020 10:57 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1743 |
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