Sijtsema, M. (2010) Behandeling van de klinische NO hals bij kleine (Tl) mondholtecarcinomen : Retrospectieve studie bij 98 patienten met een TlNO plaveiselcelcarcinoom van de mondholte. thesis, Dentistry.
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Abstract
Introduction: There is controversy in the interpretation of the treatment of the NO neck in small (T1) SCC of the oral cavity. Although there is a guideline for the treatment, it leaves room for interpretation. This research examined whether there is a difference in the prognosis for performing a SND and a wait-and-see policy. Patients and methods: The patient cohort consisted of 98 patients diagnosed with T1NO SCC of the oral cavity received in the period 1995-2005. Data (patient data, tumor data, treatment data, follow-up) were collected and entered into a spreadsheet. Statistical tests (Kaplan Meier survival curves and a logistic regression) were performed using SPSS. Results: Of the 58 patients with a wait-and-see policy, there were 9 patients developed a conversion to the neck (15.5%). Of the 40 patients with SND, there were 3 (7.5%) a conversion to the neck (p-value 0.234). Of the 58 patients with a wait-and-see policy, there are 25 deceased patients. Of the 40 patients with SND, there are 13 deceased patients (pvalue 0.290). The five years survival for conversion to the neck in a wait-and-see policy was 83.5%. The five years survival for conversion to the neck was SND 94.7%. The five years survival to mortality in a wait-and-see policy was 67 .5%. The five years survival with a mortality was SND 84.6%. The logistic regression showed no significant difference in the influence of the independent variables (smoking, alcohol, age, gender, tumor size and invasion depth) on the dependent variables: conversion yes/no and mortality yes/no. Discussion: The probability of conversion to the neck is not absent after an SND in the treatment of small T1NO SCC of the oral cavity. The probability of conversion to the neck is greater in a wait-and-see policy than after a SND. SND affects the prognosis in a positive way compared tot the prognosis for a wait-and-see policy of the neck. Our findings are based on a relatively small research group. Conclusion: Based on our findings seem a SND indicated for the treatment of small T1NO SCC of the oral cavity. This was shown both by the percentage of conversions and the survival to conversion and death. Recommendations for further research are expanding the research and data regarding the depth of tumor invasion and the size of the tumor accurately capture.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Begeleider: and Schepman, Dr. K.P. and afdeling Mondziekten, kaak- en aangezichtschirurgie and Centrum Groningen (UMCG) and Medebegeleiders: and Roodenburg, Prof. dr. J .L.N. and afdeling Mondziekten, kaak- en and aangezichtschirurgie, sectie oncologie UMCG and Dijk, Dr. B.A.C. van afdeling onderzoek van het Integraal Ka |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:56 |
| Last Modified: | 25 Jun 2020 10:57 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1713 |
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