“Cardiovascular magnetic resonance imaging and echocardiography in gout”

Stob, M.S. (2014) “Cardiovascular magnetic resonance imaging and echocardiography in gout”. thesis, Medicine.

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Abstract

Recent studies have shown an increased cardiovascular (CV) risk amongst patients with gout. Gout is a common worldwide disease, particularly amongst men, characterized by recurrent arthritis. Most accepted theory for the increased CV risk amongst patients with gout is the impact of chronic inflammation, which may promote atherogenesis and thrombogenesis. Using cardiac imaging such as echocardiogram and cardiac MRI (CMR), we hope to distinguish patterns of subclinical cardiovascular dysfunction. 10 men with intermittent or chronic gout and a minimal increased cardiovascular risk profile were included. 6 participants underwent both CMR and echocardiogram, 1 subject only had CMR. Usual echocardiographic parameters used for analysis of left ventricle (LV) function showed normal values. Remarkable, diastolic function was impaired in 83.3% of all participants, accompanied by enlargement of the left atrium. A total of 66.6% showed grade I and 16.6% showed grade II diastolic dysfunction. These percentages are higher than the normal prevalence (29.8%) of diastolic dysfunction amongst a healthy population in the same age-group. Because of the small study population it is impossible to say if the onset of symptoms, number of affected joints or the presence of tophi are of influence on the chance to develop diastolic dysfunction. CMR showed no abnormal parameters, especially no signs of edema or scarring in the myocardium. This study shows an increased prevalence of diastolic dysfunction in male patients with intermittent or chronic gout. Further research is needed to test these findings. Prospective studies with long follow-up can be useful to contribute to the concept of gout as an independent risk factor for diastolic dysfunction.

Item Type:	Thesis (Thesis)
Supervisor name:	Wagenaar, L.J. MD and Vonkeman, H.E. MD and Medisch Spectrum Twente, Enschede. and Gorselen, E.O.F van MD and Slingeland Ziekenhuis, Doetinchem
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:56
Last Modified:	25 Jun 2020 10:56
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1697

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