Physical Actvity (PA), High Sensitive Troponin T (hs-TnT) and mortality in renal transplant recipients (RTR’s)

Stevenson, M. (Marc) (2013) Physical Actvity (PA), High Sensitive Troponin T (hs-TnT) and mortality in renal transplant recipients (RTR’s). thesis, Medicine.

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Abstract

Introduction: Although a succesfull renal transplantation is accompanied by 10- to 20-year increase in life expectancy risk factors for cardiovascular disease (CVD) in renal transplant recipients (RTR’s) remain unchanged after the transplantation. Furthermore the annual risk of CVD mortality is 3.5% to 5%, this is an 50-fold increased risk when RTR are compared to a person from the general population. Physical activity (PA) is known to be a risk factor for cardiovascular (CV)- and all-cause mortality in RTR. Hs-TnT is a marker for cardiac cell death. We studied whether RTR’s with low PA are more likely to die, and in what way hs-TnT interacts in this process. Materials and methods: 540 RTR’s who came to the outpatient clinic between 2001 and 2003 were studied. CV death was recorded until May 2009, and all-cause mortality until April 2012. PA was assessed using two validated questionnaires (Tecumseh Occupational Activity Questionnaire and the Minnesota Leisure Time Physical Activity Questionnaire). Hs-TnT was measured on a Roche Modular E170 (Roche Diagnostics, Mannheim, Germany), with a lower detection limit of 0.003 µg/L. Results: Independent of age, both PA and hs-TnT were independent predictors for CV- and all-cause mortality. Cox regression analysis, with possible confounders for mortality did not significantly alter these associations. Conclusions: RTR’s with cardiac ischemia and low PA levels are at highest risk of dying. Whereas RTR’s without cardiac ischemia who are physically active have the highest survival rates. Furthermore it seems that RTR’s with cardiac ischemia are protected from dying by high PA levels. Based on the results of this cross-sectional study, for the future it seems possible to intervene on PA levels, to determine whether high PA levels will lower mortality risk.

Item Type:	Thesis (Thesis)
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:56
Last Modified:	25 Jun 2020 10:56
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1696

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