Knops, J.L. (2019) The Forced Oscillation Technique as measure and predictor for assessing asthma (control) in children aged 4-18 years: a retrospective study. thesis, Medicine.
Full text available on request.Abstract
Background: In young children asthma is one of the most common chronic diseases. Asthma diagnosis and control status is difficult to assess, especially in children under 6 years of age. Using FOT as non-invasive and non-obtrusive technique allows lung function testing at the age of 4 years old. This helps assessing and predicting asthma in young children and provides early treatment. However, the relation between FOT and spirometry is not fully understood and more research is required, especially in patients with exercise induced asthma. In this study we compare the dynamics of spirometry and FOT during an ECT to determine whether FOT is a valid tool to identify bronchial lability. Methods: Retrospective study (n=98). Children, aged 4-18 years, measured on spirometry and FOT before and after an exercise challenge test and no history of prematurity or other conditions were included in a controlled (n=42) and uncontrolled asthma group (n=56) based on lability and reversibility in FEV1. Results: A relation was seen between spirometry and FOT. This relationship is at its best when FEV1 and R5 are compared at the baseline measurement r=-0,89 (p<0,001) and R2 is 0,78. Little correlation is seen between reversibility in FEV1 and different FOT indices. However, a predictive model shows that the decrease in X5 after ECT compared to baseline proves to be the best predictor for asthma control status, positive predicted value is 81% (sensitivity 91%, specificity 52%). Conclusions: A prediction model for assessing asthma control status using FOT can be made and our study proved this to be a reliable desk tool in clinical practice. Besides we found a strong correlation between R5, X5 and Ax and FEV1 measured at baseline. A weaker correlation exists after ECT and administering salbutamol. More prospective research is needed to validate our results in patients with EIB against a healthy control group.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Thio, Dr. B. Location: Medisch Spectrum Twente |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:56 |
| Last Modified: | 25 Jun 2020 10:56 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1686 |
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