The influence of current vitamin D levels on the outcome of a double-blind, placebo-controlled food challenge.

Kuijk, E. (Emma) (2014) The influence of current vitamin D levels on the outcome of a double-blind, placebo-controlled food challenge. thesis, Medicine.

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Abstract

Introduction: The prevalence of food allergy in the North America and Europe is considered to be 3-8 percent. The prevalence of vitamin D deficiency in industrialized countries is estimated to be 10%, with the prevalence of vitamin D insufficiency estimated to be 50%. A link between food allergy and vitamin D deficiency and vitamin D insufficiency was proposed when recent research found a higher incidence of food allergy in countries located further from the equator. Methods: We examined 561 patients who had undergone double-blind, placebo-controlled food challenges (DBPCFCs), 293 of which were considered tolerant, and 268 of which were considered allergic. Blood samples from these patients were taken for vitamin D determinations via LCMS. Patients who had undergone DBCFCs for peanut were then also examined separately. Statistical analysis was performed with the help of IBM SPSS 21. Results: In total 10% of our patients in both the tolerant and allergic group were considered vitamin D insufficient (blood concentration ≤50nmol/L). No significant difference between the vitamin D levels was found in the tolerant and allergic group (p=0,685). Similar results were obtained for the peanut subgroup (p=0,486). No effect from vitamin D levels on tolerance could be demonstrated in either the larger (p=0,741) or peanut subgroup (p=0,618) when corrected for confounders by means of regression analysis. Conclusion: No effect of vitamin D levels on the outcome of DBPCFCs could be demonstrated. Vitamin D levels in childhood may be less relevant in the development of food allergy than those occurring in the first year of life.

Item Type:	Thesis (Thesis)
Supervisor name:	Dubois, Prof. Dr. A.E.J.
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:56
Last Modified:	25 Jun 2020 10:56
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1669

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