Croes, N.F. (Nicolle) (2019) Antidepressant exposure during pregnancy and its effect on pregnancy and birth outcomes: a population-based cohort study. thesis, Medicine.
Full text available on request.Abstract
Objective- To determine whether SSRI use is associated with adverse pregnancy and birth outcomes. Methods- We carried out a Dutch-population based retrospective cohort study from 1999- 2014. Data was collected by the PHARMO and PRN databases on 33559 pregnant females. Data of females with registered SSRI dispensation (before, during or after pregnancy) were matched (ratio 1:4) with data of females with no SSRI dispensation by birth year of the female, birth year of the child, nulliparity and pharmacy region. Two study groups were identified: SSRI users during pregnancy (SU+, n=2466) and non-SSRI users during pregnancy (SU-, n=31402). Results- SSRI users were generally older, had more parities and were more often of low SES (socio-economic status). Furthermore, they had a higher incidence of concomitant use of psychotropic medication. Antidepressant users had a shorter length of gestation (ßAdjusted - 0.37, 95% CI [-0.43, -0.26]) and their infants had lower birth weight (ßAdjusted -78.54, 95% CI [-103.89, -53.18]). Moreover, a higher risk of prematurity (<37 weeks) (ORAdjusted 1.24, 95% CI [1.07, 1.44], p <.001) was observed. No association was seen between SSRI use and an increased risk of SGA infants (small for gestational age: birth weight <10th percentile) (ORAdjusted 1.11, 95% CI [0.96, 1.28], p >.05). Conclusion- The use of SSRI in pregnancy may be associated with shorter length of gestation, lower birth weight and prematurity, which may be interrelated to one another.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: Mw. M.H. van de Beek, MD |
| Supervisor name: | Second supervisor: and Bais, Mw. B. and Department: Psychiatry and Hospital: Erasmus MC Rotterdam |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:56 |
| Last Modified: | 25 Jun 2020 10:56 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1668 |
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