Bosch, S. (2014) “Het gebruik van preventieve geneesmiddelen bij ouderen met dementie”. thesis, Medicine.
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Abstract
Background: Because of the physiologic changes, loss of function of different mechanisms in the human body and potentially multimorbidity, elderly are vulnerable for the harmful effects of polypharmacy, the use of >5 drugs. For elderly with a shorter life expectancy caused by dementia, a very carefully composed medication prescription is needed in order to prevent them from polypharmacy, is needed. Prescribing of preventive drugs has to be done carefully because a long ‘time until benefit’ with these drugs is common. In present researches little is known about the prescription of preventive drugs for elderly with dementia in the Netherlands. Objective: The study aims to assess the frequency and nature of preventive drugs amongst elderly with dementia Method: A retrospective analysis of medication was performed for 310 patients suffering from dementia. The statistical analyses were performed for 290 patients with dementia by applying criteria for a preventive drug, especially developed for this study. The study took place at Team 290, part of Lentis. Results: The total number of drugs prescribed is 1332, of which 618 (46, 4%) were identified as a preventive drug. 220 patients (75, 9%) used at least one preventive drug. The average amount preventive drugs is 2,1. The top 3 most frequently prescribed preventive drugs are lipid- lowering drugs (123), thrombocyte aggregation inhibitors (121) and medication against osteoporosis (90). Patients between 75 and 79 years old get a significant higher (p=0,005) average amount of preventive drugs than patients aged younger than 75 years. As at last results, patients suffering from vascular dementia or Alzheimer/vascular mixed dementia are prescribed a significant higher average amount of preventive drugs compared to patients with Alzheimer dementia or nonspecific syndrome of dementia. Conclusions/discussion: More than three quarter of the study population is prescribed one or more preventive drugs. Lipid-lowering drugs, thrombocyte aggregation inhibitors and medication against osteoporosis are the most frequently encountered preventive drugs. This is partly explained by the significant higher amount of preventive drugs use in the groups of patients with vascular dementia or Alzheimer/vascular mixed dementia.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Boersma, Dr. F. and Specialist Ouderengeneeskunde |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:56 |
| Last Modified: | 25 Jun 2020 10:56 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1621 |
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