Mousset, R.A. (2013) Stressgerelateerde veranderingen in executieve functies: Een causaal verband met depressie? thesis, Medicine.
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Abstract
Objective: Although there is growing evidence that both stress-induced alterations in prefrontal cortex (PFC) and major depressive disorder (MDD) are associated with executive function (EF) deficits, the existence and nature of EF deficits are strongly debated. The aim of this study was to longitudinally investigate the possible mediating effect of EF on the well established relationship between stress exposure and depressive disorder during adolescence. Method: A population-based sample of 1584 adolescents was assessed at four waves across a eight year interval (11-19 years). At baseline (T1) and endline (T4) adolescents performed a selection of tasks from the Amsterdam Neuropsychological Tasks (ANT) program, which enabled the assessment of maturation of the main aspects of EF. Data on adolescent stress exposure in the period between T1 and T4 were obtained from parent-report, self-report and the Event History Calendar (EHC). DSM-IV diagnosis of MDD during adolescence was made using the Composite International Diagnostic Interview (CIDI). Linear and logistic regression analysis was used analyzing continuous (EF) and dichotomous (MDD) dependent variables, respectively. Results: Although we found significant associations between stress and measures of Spatial Working Memory, Verbal Working Memory, Response Inhibition, Sustained Attention and Cognitive Flexibility at T4, stress exposure did not seem to affect maturation of EF during adolescence. While we replicated the previously found association between stress exposure and MDD, EF maturation was not associated with MDD. Conclusion: These results provide no evidence for a mediating effect of EF on the relationship between stress and depressive disorder during adolescence and suggest that associations are more complex than proposed by some researchers in the field.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Hartman, Mw. Dr. C.A. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/161 |
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