Salters, E. (Eva) (2014) CT-morphological characteristics of screen-detected lung cancer: predictors for histopathological diagnosis? thesis, Medicine.
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Abstract
This study, part of the Dutch-Belgian lung cancer screening trial (NELSON), aimed to identify CT-morphological features capable of discriminating between histopathological subtypes of lung cancer. To achieve this, a retrospective analysis of 197 solid lung cancers detected by low-dose CT screening in 192 NELSON participants was performed. Morphological CT features studied were nodule shape, margin, location and vessel attachment. Tumors were divided into four groups based on histopathology: adenocarcinoma, squamous cell carcinoma, large cell carcinoma and neuro-endocrine cancers. The majority of all types of cancer had a spherical shape. Margins were most often lobulated (39.3-45.9%) and spiculated (22.2-35.7%) without significant difference between histopathology groups. Most nodules (63.5%) were located in the upper lobes, adenocarcinoma significantly more often (71%) than other cancers. The results of this study suggest that location in the upper versus lower lobes is the only morphological feature potentially useful for differentiating between types of lung cancer in malignant nodules detected in CT lung cancer screening.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Vliegenthart, R. |
| Supervisor name: | Oudkerk, M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:55 |
| Last Modified: | 25 Jun 2020 10:55 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1584 |
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