Sodium-to-potassium ratio in patients with diabetes mellitus type 2

Jaspers, J. (Jolien) (2016) Sodium-to-potassium ratio in patients with diabetes mellitus type 2. thesis, Medicine.

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Abstract

Background: hypertension is an important modifiable risk factor for complications in patients with diabetes mellitus type 2 (DM2). Lifestyle factors that influence blood pressure include dietary intake of sodium and potassium. The ratio between sodium and potassium intake is associated more strongly with blood pressure and cardiovascular disease than sodium or potassium independently. It is yet unknown whether the sodium-to-potassium ratio in patients with DM2 is different from the ratio in people without diabetes. Objective: this study aims to determine the sodium-to-potassium ratio in patients with DM2 and compare it with the sodium-to-potassium ratio in people without diabetes. It will also investigate associations of the sodium-to-potassium ratio with blood pressure and kidney function at baseline, and with development of complications during follow-up. Methods: 375 patients with DM2 were included in this cross-sectional cohort study. Sodium and potassium excretion were determined from a 24-hour urine collection. Dietary data were available for 270 patients. 305 patients were included in follow-up, with patient files being reviewed for cardiovascular disease, renal disease and microvascular complications of DM2. Data from 68 patients with non-diabetic chronic kidney disease and 41 healthy controls were used to compare the sodium-to-potassium ratio of patients with DM2 and people without diabetes. Results: the average sodium-to-potassium ratio in this population was 2.52 ±0.98. Healthy controls had a significantly higher potassium excretion, but the sodium-to-potassium ratio was not significantly different (2.23 in healthy controls versus 2.52 in patients with DM2, P=0.067). Sodium-to-potassium ratio was not associated with blood pressure or kidney function at baseline. Patients who experienced microvascular complications during follow-up had a higher sodium-to-potassium ratio at baseline (2.78 versus 2.42 in patients who did not develop microvascular complications, P=0.004). Conclusions: in this population of Dutch patients with DM2, the average sodium-to-potassium ratio of 2.52 was not significantly different from the ratio in people without diabetes. No associations with blood pressure and kidney function were found. Development of microvascular complications was associated with a higher sodium-to-potassium ratio at baseline.

Item Type:	Thesis (Thesis)
Supervisor name:	Supervisors: and Laverman, G.D. and Gant, C.M. and ZGT Almelo, Department of Internal Medicine
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:55
Last Modified:	25 Jun 2020 10:55
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1569

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