Parkinson’s KinetiGraph: Are motor fluctuations in Parkinson disease correlated with disease duration?

Berghuis, E.J.J.M. (2016) Parkinson’s KinetiGraph: Are motor fluctuations in Parkinson disease correlated with disease duration? thesis, Medicine.

Text BerghuisEJJM.pdf Restricted to Registered users only Download (894kB)

Abstract

Introduction After 5 years of treatment, Parkinson’s Disease (PD) patients can experience motor fluctuations. The severity of these fluctuations is mostly measured by clinical rating scales. However, these measurement systems have limitations. Recently, the Parkinson’s KinetiGraph (PKG) has been developed to measure fluctuations. The aim of this study is to investigate whether the motor fluctuations measured by the PKG, expressed as fluctuation score (FS), is correlated with disease duration of PD patients. Material and Methods This retrospective study was performed in the Medical Centre Leeuwarden (MCL). Seventy-two PKG measurements together with demographic information, clinical data and disease duration (using date of diagnosis till date of PKG measurement) were collected from 66 PD patients. Spearman’s rho correlation coefficient was used to calculate the correlation between disease duration and FS. Additionally, patients were categorized in four disease duration categories/groups: 0-4 years, 5-7 years, 8-10 years and ≥11 years. Differences in FS between the groups was investigated using the Kruskal-Wallis. Results The mean age of the patients is 71.2 years (SD ± 8.28) with a disease duration that varies between 1 and 27 years. No correlation (correlation coefficient was 0.020) between disease duration and FS was found. Between the different disease duration groups no significant difference was found in the medians (min-max) of the FS score (0-4 years: 7.80 (4.50-12.50); 5-7 years: 9.50 (5.10-16.80); 8-10 years: 9.00 (5.40-19.40) and ≥ 11 years: 7.65 (5.00-13.20), with p=0.292). However, between the different disease duration groups a trend for a parabolic configuration was seen in FS. In the first three categories (0-4 years, 5-7 years, 8-10 years) an increase in FS is present, in the last category (≥ 11 years) the fluctuation score decreases with respect to the first group. Conclusions Possibly, in the course of Parkinson disease, motor fluctuations does increase, however in end-stages of this disease FS will decrease. Probably, more patients have to be measured to increase the power of this effect.

Item Type:	Thesis (Thesis)
Supervisor name:	Department of Neurology, Medical Centre Leeuwarden and Supervisors: and Verwey, dr. N.A.neurologist and Kappelle, dr. J.W. faculty supervisor
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:54
Last Modified:	25 Jun 2020 10:54
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1503

Actions (login required)

View Item