Ahrens, P.R. (Philipp Robin) (2014) Can a minimally invasive HVAD implantation become the new gold standard in advanced heart failure treatment? thesis, Medicine.
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Abstract
Heart failure is a major cause of death in developed countries. Today cardiac transplantation is frequently considered the best possible treatment for end-stage heart failure once standard therapy has failed. Cardiac transplantation has well known risks and disadvantages, availability of donor organs being one of them. For people awaiting cardiac transplantation the mortality rates at one and five years are respectively 30% and 50%; clearly there is an urgent need for alternative treatment options. (1,2) With more than 50 years of technical engineering research in this field, potential alternatives to cardiac transplantation have become available. Mechanical circulatory support (MCS) being one of them. Implantation of a left ventricular assisting device (LVAD) has evolved from use as a bridging technology whilst awaiting transplantation, to a longterm treatment option for end-stage heart failure. Unfortunately the implantation procedure is associated with a high rate of complications and is therefore limited to severely ill patients only. The most recent evolution of surgical LVAD implantation is a novel technique employing a minimally invasive left-sided anterolateral thoracotomy instead of a full sternotomy. With this novel technique complications can possibly be reduced and this therapy option could become available to the broader population. In this study I compared the conventional technique with the novel minimally invasive technique in terms of survival and overall outcome. My findings suggest that the novel technique is superior compared to the conventional method and may even offer an alternative to heart transplantation.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Boer, Dr. R.A. de and Cardiologist UMCG |
| Supervisor name: | External attendant: and PD. Dr. med. J.D. Schmitto and HTTG (Department of Cardiothoracic and Transplantation and Vascular Surgery) and External Institution: Hanover medical school (MHH) and Germany |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:54 |
| Last Modified: | 25 Jun 2020 10:54 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1460 |
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