Hertog, M. den (Marleen) (2017) Lifestyle as a Risk Factor for Incident Atrial Fibrillation. thesis, Medicine.
Full text available on request.Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF risk factors are diverse. Management of modifiable risk factors (e.g. hypertension) may be of importance for the prevention of AF and its disease burden. Currently, the pathophysiology of AF is only partially explained. This database study explored the associations between lifestyle and incident AF, with lifestyle being expressed as dietary factors, subscapular skinfold thickness, and physical activity. Data were retrieved from the Zutphen Study cohort concerning male residents of Zutphen who were born between 1900-1919. Incident AF was ascertained by coded electrocardiograms. During 14.7 ± 7.0 years of follow-up, 32 of the 838 men developed AF (3.8%). Because AF can present as stroke, a combined endpoint was formed (with a total of 106 events). At baseline increased height, weight, basal metabolism, total energy consumption, and intake of high-fiber cereal products were associated with AF. Univariate cox regression associated alcohol intake with AF (hazard ratio 1.12 [1.04-1.21], p = 0.004). Advancing age, higher body mass index (BMI), subscapular skinfold thickness, and resting heart rate, were associated with increased risk for AF or stroke. Inactivity increased the risk for AF or stroke (odds ratio 1.02 [1.00-1.03], p = 0.012), while more time spent on low- to moderate activities decreased the risk (odds ratio 0.97 [0.95-1.00], p = 0.015). The intake of sugar products (odds ratio 0.62 [0.40-0.98], p = 0.041) and sodium (hazard ratio 0.74 [0.62-0.88], p < 0.001) had a protective effect. Previous myocardial infarction, diabetes mellitus, and obesity were associated with AF or stroke. The present study confirmed lifestyle to be associated with incident AF (or stroke). Because of conclusions based on small event groups, further research is advised.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Gelder, Prof. Dr. Isabelle C. van and University Medical Center Groningen – Cardiology Department |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:54 |
| Last Modified: | 25 Jun 2020 10:54 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1452 |
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