The impact of different nCRT schedules on localization of tumor recurrences in esophageal cancer patients

Jipping, K. (2016) The impact of different nCRT schedules on localization of tumor recurrences in esophageal cancer patients. thesis, Medicine.

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Abstract

Background: Identification of a different distribution and pattern of recurrent disease in esophageal cancer (EC) patients is important for a better understanding of tumor biology and the effect of neoadjuvant chemoradiotherapy (nCRT). This study assessed the influence of two different nCRT regimens (cisplatin/5-fluorouracil with 50.4 Gy (Cis/5FU) versus carboplatin/paclitaxel with 41.4 Gy (CROSS)), on the distribution of recurrent disease and distant metastases in EC patients. Patient and Methods: In this retrospective study, locally advanced EC patients (stage II/III) treated between 2002 and 2015 with nCRT followed by a curative intended esophagectomy (open transthoracic or scopic procedure), were included. The CROSS patients were all treated in the University Medical Center Groningen in The Netherlands and the Cis/5FU patients were treated in the Flinders Medical Centre in Australia. We assessed the difference in site-specific tumor recurrence. We also assessed the 5-year overall survival (OS) and 5-year disease-free survival (DFS) with univariate and multivariate Cox regression analysis. Results: One hundred and thirty-eight (n=138) EC patients were included in analysis. The amount of distant metastases (P=0.039), lung metastases (P=0.017), and peritoneal metastases (P=0.039) differed significantly between the groups. The treatment schedule was not a prognostic factor in multivariate Cox regression analysis for both 5-year DFS (P=0.232) and 5- year OS (P=0.602). Conclusion: The CROSS and Cis/5FU group differed significantly in the total amount of recurrences, with more tumor recurrences in the CROSS group. However, the 5-year OS and DFS did not differ.

Item Type:	Thesis (Thesis)
Supervisor name:	Supervisor: and Plukker, Prof. Dr. J.T.M. and Department of Surgical Oncology and University of Groningen and University Medical Center and Groningen/Flinders Medical Centre
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:53
Last Modified:	25 Jun 2020 10:53
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1425

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