Everdink, J. van (Jildou) (2015) Het verschil in trefkans voor verklarende pathologie bij colonoscopie en gastroscopie in het kader van de diagnostiek van ferriprieve anemie tussen patiënten die wel en geen antithrombotica gebruiken. thesis, Medicine.
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Abstract
Purpose: To determine whether the use of antithrombotics is a negative predictive factor for finding explanatory pathology in gastroscopy and/or colonoscopy in patients with iron deficiency anemia. Methods: This study was a retrospective record search. The study population was based on patients who for the purpose of the diagnostics of iron deficiency anaemia had undergone a gastroscopy and/or colonoscopy in the Scheper Hospital in Emmen in the period 2010-2014. The study compared two groups. The first group consisted of patients who were not taking antithrombotics at the time of, and six months prior to colonoscopy or gastroscopy. The second group consisted of patients who used antithrombotics at the time of, and at least six months prior to the colonoscopy or gastroscopy. Data were collected on whether and which antithrombotic agents were used, whether explanatory pathology was found and whether the scopy was relevant. A scopy could still be relevant, despite the fact that no explanation was found, when there was another important finding, like a premalignant lesion. Results: In total, 448 patients were included. 251 patients were using antithrombotics and 197 patients were not using antithrombotics. It was shown that in patients taking antithrombotics, explanatory pathology was found significantly less often at colonoscopy and gastroscopy, than in patients with iron deficiency anaemia who did not use any antithrombotics (P = 0.049 ; odds ratio 1.553). This difference seemed to consist mainly with the use of a salicylate (P = 0.011 ; odds ratio 2.034). For the use of a coumarin, no difference was found (P = 0.417). There was no difference between the two groups in how often patients had undergone relevant scopy (P = 0.628). Especially with colonoscopy, less explanatory diagnoses were found in the group that used antithrombotic agents (P = 0.001). For gastroscopy, no difference in the number of explanatory diagnosis was found between the two groups (P = 0.290). Conclusion: At the diagnostics of iron deficiency anaemia in patients on antithrombotics, explanatory pathology is found significantly less often at colonoscopy and gastroscopy, than in patients with iron deficiency anaemia who are not using antithrombotics. However, it appears that patients who use antithrombotics undergo a relevant scopy as often as patients who not use antithrombotics.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Kleij, Dhr. dr. F.G.H. van der and Scheper Ziekenhuis te Emmen and interne geneeskunde |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:53 |
| Last Modified: | 25 Jun 2020 10:53 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1413 |
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