Dalen, R.C. (Runa) (2016) Neonatal sepsis incidence in preterm infants treated with standard care in an open bay in a level 2 Neonatal ward,2009-2012. thesis, Medicine.
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Abstract
Background and objective Neonatal sepsis is a severe disease in preterm infants that can result in significant morbidity in this vulnerable patient group. Our aim was to identify and assess the risk factors and incidence of neonatal sepsis in two different groups of preterm infants (very preterm-and moderate to late preterm infants) in a level 2 neonatal ward. Methods We conducted a retrospective cohort study in preterm infants with a gestational age (GA) of <36weeks transferred to or born in our centre from 2009 to 2012. Sepsis was defined as a positive blood culture and clinical symptoms, with early -and late onset sepsis defined as onset of symptoms before 72 hours and after 72 hours of life, respectively. Univariate and multivariate logistic analyses were performed. Results We included 163 very preterm infants (GA<32weeks) and 434 moderate-to late preterm infants (GA 32-36weeks). Neonatal sepsis was found in 6% (36/597) of preterm infants. There was a significant association between the type of group a neonate belonged to (according to GA) and whether or not sepsis was diagnosed (p < 0.002). The odds of sepsis for neonates were 2.7 times higher if they were born with a GA <32 weeks (group A) than if they were born with a GA 32- 36 weeks (group B). Early-onset sepsis (EOS) with group B streptococcus occurred in one late preterm infant (0.7%) of 146 suspected episodes. Lateonset sepsis (LOS) occurred in 35 preterm infants of a total of 90 suspected episodes (39%). Coagulase-negative staphylococci was the most frequently pathogen isolated in LOS. Total parenteral nutrition administration, vaginal spontaneous birth and gestational age were significantly associated with LOS. Conclusion This study shows a very low prevalence of EOS and LOS in both very preterm and moderate preterm infants. Vaginal spontaneous birth was found to be a significant protective factor for LOS. TPN administration (by central venous catheter, peripheral inserted catheter), vaginal spontaneous birth and lower GA were found to be significant risk factors for development of LOS.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Koper, Drs. J. F. neonatologist and UMCG, the Netherlands |
| Supervisor name: | Second supervisor: and Schoor, Dr. S.R.D. van der and neonatologist and OLVG East, the Netherlands |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:53 |
| Last Modified: | 25 Jun 2020 10:53 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1394 |
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