The association between Restless Legs Syndrome and musculoskeletal pain in young adults: a cross-sectional study in the Western Australia Pregnancy (Raine) Cohort.

Hoogwout, S.J. (2015) The association between Restless Legs Syndrome and musculoskeletal pain in young adults: a cross-sectional study in the Western Australia Pregnancy (Raine) Cohort. thesis, Medicine.

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Abstract

Background: Several studies have reported an association between multi-site pain and restless legs syndrome (RLS) in middle-aged females. The current study explored the association between musculoskeletal (MS) pain and RLS in young adults of both sexes. Methods: Subjects from the Raine Study cohort (n=1076; aged 22 years), provided data on anthropometrics, MS pain (Orebro Musculoskeletal Pain Questionnaire), sleep quality, physical activity and Depression, Anxiety and Stress Scale [DASS-21]. Participants were considered to have RLS when all 4 RLS diagnostic criteria recommended by the International Restless Legs Syndrome Study Group were met and had restless legs at least 5 times per month. Associations between MS pain characteristics (duration, intensity, frequency and number of pain sites) and RLS were analyzed with Chi-squared tests and multiple logistical regression analysis. Final models were adjusted for sex, DASS-21 scores and sleep quality. RLS-diagnosis group was compared with the remaining participants without RLS-diagnosis as the reference group. Results: Prevalence of RLS was 3.1% and MS pain was reported by 37.4% of the participants. Significant differences between the RLS-diagnosis group and the reference group were found on all MS pain characteristics. In multiple logistical regression models significant associations between RLS-diagnosis and long duration (three months or more) of MS pain (odds ratio 3.6, 95% confidence interval 1.5-8.4); severe pain intensity in the last three months (3.1, 1.1-9.2); high weekly frequency of pain (3.1, 1.1-8.9) and three or more pain sites (3.5, 1.2-9.6) were found. Conclusions: Multiple dimensions of MS pain were strongly associated with RLS in young adults, suggestive of shared pathophysiological mechanisms. The overlap between these conditions requires more clinical and research attention.

Item Type:	Thesis (Thesis)
Supervisor name:	Palen, prof. dr. J.A.M. van der
Supervisor name:	Champion, associate prof. D. and Pain Research Unit and Sydney Children’s Hospital and Sydney, Australia
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:53
Last Modified:	25 Jun 2020 10:53
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1391

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