Stormezand, G.N. (2012) Implementation of quantitative techniques for detection of cerebral perfusion territories with arterial spin labeling MRI. thesis, Medicine.
Full text available on request.Abstract
Background: Arterial Spin Labeling (ASL) is a recently developed method that enables non-invasive and quantitative measurements of cerebral blood flow. This technique could be of great value in the choice of treatment in patients with cerebrovascular disease, but has not yet been fully developed in the UMCG. To implement the ASL technique a study was initiated to investigate whether the configuration of the circle of Willis influences the distribution of perfusion territories of the brain feeding arteries. For this purpose selective ASL is applied. Using selective ASL it is possible to visualize the perfusion territories of the brain feeding arteries. Methods: A novel selective ASL approach was implemented at our institution: vessel- encoded pseudocontinuous ASL (VE-pCASL). 31 healthy volunteers were investigated. The MRI protocol consisted of VE-pCASL, pCASL, 3D time-of-flight (TOF) MRA and phase contrast (PC) MRA. It was investigated whether morphological and hemodynamic characteristics of the circle of Willis were related to the distribution of perfusion territories of the brain feeding arteries. Results: A significant relationship was found between the presence of a hypoplastic A1 segment, a common trunk arising from the anterior cerebral arteries (ACA), a fetal type posterior cerebral artery (FTP) and the distribution of perfusion. In subjects with a hypoplastic A1 segment and a common trunk arising from the ACAs an increase in carotid perfusion towards the contralateral hemisphere was observed, whereas in subjects with a FTP an increase of carotid perfusion towards the territory of the posterior cerebral artery was noted. Conclusion: In healthy volunteers a considerable variability in perfusion territories of the brain feeding arteries exists. To a large extent this variability can be attributed to the configuration of the circle of Willis. Knowledge of the anatomy of the circle of Willis and underlying perfusion territories could be of great value in targeting, monitoring and explaining differences in outcome of cerebrovascular interventions
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Groot, dr. J.C. de neuroradioloog UMCG and Renken, dr. R.J. MR-fysicus NIC and Plaats:Afdeling radiologie UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:53 |
| Last Modified: | 25 Jun 2020 10:53 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1373 |
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