Ploeger, H.E. (Hilde) (2009) Inflammatory and growth factor responses to continuous and intermittent exercise in youth with Crohn's disease. thesis, Human Movement Sciences.
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Abstract
Purpose: Acute bouts of exercise might amplify the inflammation underlying the pathology in youth with Crohn's Disease (CD). The type of exercise that stimulates growth factors but does not exacerbate the inflammation in CD is unknown. We therefore examined the response of markers of inflammation and growth factors to acute bouts of moderate intensity continuous exercise (MICE) and high intensity intermittent exercise (HIIE) in youth with CD. We also investigated the relationship between the degree of inflammation during and following an acute bout of exercise and levels of physical activity. Patients and methods: Fifteen patients performed both the MICE (2 x 30 min of cycling at 50% of peak mechanical power (Wpeak) at 60 rpm) and the RITE (6 bouts of 4 x 15-sec of cycling at 100% of Wpeak at 60 rpm). Blood was collected at rest (REST), at the mid-point of exercise (EX-50%), at the end of exercise (EX-100%) and at 30 (REC-50%) and 60 min (REC-1 00%) after the end of exercise. Physical activity was measured for seven consecutive days using accelerometers. Results: Both MICE and HIIE induced an increase in total leukocytes, neutrophils, lymphocytes, monocytes and GH and a decrease in IGF-I. MICE induced a greater increase in leukocytes (p < 0.05), neutrophils (p < 0.05), lymphocytes (p < 0.001), monocytes (p < 0.05), IL-6 (p < 0.05) and GH (p < 0.05) and a similar decrease in IGF-I compared with HIIE. For MICE, leukocytes and neutrophils continued to increase into the recovery period, lymphocytes increased during and directly after the exercise and returned to baseline levels at REC-50%, and monocytes increased at EX-100% and remained elevated during the entire hour of recovery. IL-6 increased at EX-100% and returned to baseline levels at REC-100%. No change in IL-6 was detected following HIIE. IGF-I decreased during exercise for both MICE and HIIE and returned to baseline levels at REC-50%. TNF-a did not change significantly for either exercise. No correlations were found between physical activity and levels of inflammation both at rest and in response to exercise. Conclusion: Both types of acute exercise did not exacerbate the levels of measured proinflammatory cytokines underlying the pathology in CD. Decreases in IGF-I were similar between the exercises; however, the GH response in MICE was greater than in HIIE.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Greef, Mathieu H. G. de |
| Supervisor name: | Obeid, Joyce and Nguyen, Thanh and Takken, Tim and Timmons, Brian W. and Children's Exercise and Nutrition Centre, Department of Pedi and McMaster University, Hamilton and Wilhelmina Children's Hospital and University Medical Center Utrecht, Utrecht and Issenman, Robert M. and Pediatric Gastroenterology and Nutrition, McMaster Universit |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:52 |
| Last Modified: | 25 Jun 2020 10:52 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1317 |
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