Veldhof, T.J. (2017) The association of tic disorders and its psychiatric comorbidities with allergic diseases: a family-based case-control study. thesis, Medicine.
Full text available on request.Abstract
Objective: We aimed to investigate the association of chronic tic disorders (CTD) and comorbid psychiatric conditions [i.e., obsessive-compulsive disorder (OCD) and attentiondeficit hyperactivity disorder (ADHD)] with asthma, allergic rhinitis, eczema and food allergies. Methods: Data in this study was obtained from the TIC Genetics Study containing subjects with tic disorders, with or without comorbid OCD and/or ADHD and unaffected family members. Psychiatric diagnoses were made following interviews with board-certified clinicians and allergic disease diagnoses were self-reported. We formed various diagnostic groups (i.e., CTD only, OCD only, CTD+OCD, CTD+ADHD and CTD+OCD+ADHD) based on the assigned psychiatric diagnoses, to identify the potential specific role of CTD, OCD and ADHD in allergic disease prevalence. We performed logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (CIs) for each diagnostic group versus family controls, separately for each investigated allergic disease, as well as for compound measures defining the presence or absence of any allergic disease, and the number of allergic diseases. Results: Asthma showed strong associations with CTD, with or without comorbid OCD and/or ADHD, as the CTD-only, CTD+OCD and CTD+OCD+ADHD groups gave OR=1.67, p=0.024; OR=1.96, p=0.001 and OR=2.63, p<0.000, respectively. Allergic rhinitis was associated with OCD, with or without comorbid CTD and/or ADHD, as OCD-only, CTD+OCD and CTD+OCD+ADHD gave OR=1.39, p=0.056; OR=1.47, p=0.006 and OR=1.64, p=0.002, respectively. Presence of CTD and/or OCD was also associated with having more allergic diseases in general and having more allergic comorbidities. Eczema was not associated with any diagnostic group and food allergies were only marginally significant in the CTD+OCD and CTD+OCD+ADHD subgroups. Comorbid ADHD with CTD+OCD had a significant effect on asthma prevalence, however comorbid ADHD with CTD may represent a distinct subtype as no clear associations were found at all in each allergy variable. Due to sample size restriction the effects of ADHD without comorbidity could not be investigated. Conclusions: Our results showed allergic diseases to be more prevalent in individuals with CTD and/or OCD, thus we recommend appropriate screening of comorbid allergic diseases in these patients. Further investigations in large-sized epidemiological samples, appropriate case-control matching, and adequate allergy testing are required.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Hoekstra, Prof. Dr. P.J |
| Supervisor name: | Secondary supervisor: and Dietrich, Dr. A. and Accare, Kinder- en Jeugdpsychiatrie. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:52 |
| Last Modified: | 25 Jun 2020 10:52 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1312 |
Actions (login required)
 |
View Item |