Feenstra, F.A. (Folmar) (2015) Verandering van serum bot-turnover parameters na het uitvoeren van een bisaggitale splijtingsosteotomie; pilot-studie. thesis, Dentistry.
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Abstract
Objective: Little is known about the normal values in the remodeling of the mandible. The relatively small dimensions makes it is even questionable whether the remodeling of this bone turns out to be detectable in the serum. To determine the values of the normal remodeling, a Bilateral Sagittal Splitting Osteotomy (BSSO) of the lower jaw has been used as a research model. This pilot study investigate the measurable changes of certain serum bone turnover parameters (BTM) during the postoperative period. Method: twenty patients between 18 and 62 years whereby a BSSO was to be performed were included. Patients with medical conditions and interfering medication are excluded as much as possible. Preoperatively, and post-operatively serum samples are collected on day 1, 10, 30, 90 and 180. The bone parameters of osteocalcin, BALP, PINP and sCTX are compared with reference values of a healthy population with same age and sex (Z scores). The statistical analysis were performed with SPSS 22.0 software (SPSS, Chicago, IL, USA) Differences between the points of measuring are evaluated by repeated measures ANOVA, followed subsequently with a paired t-test which assesses the significantly differences between the points of measurement. P values <.05 were considered as statistically significant. Results: The mean age at surgery (n = 20) was 31.6 (SD ± 13.0), of which 13 men and 7 women. Complete data were obtained from 8 to 10 patients for the first four measurement points. The inflammation parameters (leucocytes, CRP, IL-6) are significantly elevated during the first period of the recovery process and almost back to normal after ten days. BSE is significantly increased after 10 days and after a month again equal to preoperatively values. There are significant differences found in the BTM between the individual measuring points during the recovery process, which can be explained by perioperative medication use and methodology of serum sampling. Conclusion: Postoperative after a BSSO the bone remodeling is not observable with BTM values. The inflammatory symptoms are already disappeared after 10 days. The perioperative medication significantly reduced osteocalcin and PINP values on day 1 postoperatively.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Witjes, Dr. M.J.H. and Veer, Mw. Dr. E. van der |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:52 |
| Last Modified: | 25 Jun 2020 10:52 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1292 |
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