Houwen, B. (Britt) (2014) De associatie tussen de dode ruimte en de beademingsduur bij mechanisch beademde kinderen met acute longschade. thesis, Medicine.
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Abstract
The aim of this prospective observational feasibility study was to evaluate the utility of pulmonary dead space fractions and the pulmonary alveolar dead space to predict the risk for prolonged mechanical ventilation and length of hospital stay in children admitted to a pediatric intensive care unit (PICU). We measured the prognostic value of pulmonary dead space fraction and alveolar dead space as a non-invasive maker in 30 pediatric patients aged 0-5 years within 24 hours from intubation. Dead space measurements were obtained with a bedside AVEA ventilator. Median pulmonary dead space fraction was 0.39 (25-75% IQR 0.25-0.61). Pulmonary dead space fraction and alveolar dead space are not significantly correlated with duration of mechanical ventilation and length of hospital stay in the entire cohort (VD/VT : rs=0.11, P=0.569, rs=0.30, P=0.116) ( VDalv: rs=0.32, P=0.081, rs=0.50, P=0.005). Elevated pulmonary dead space fraction and alveolar dead space are not associated with prolonged ventilation and hospital stay in pediatric patients who need mechanical ventilation, but they have an additive predictive value in identifying those at risk for longer duration of mechanical ventilation.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Kneyber, dr. M.C.J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:52 |
| Last Modified: | 25 Jun 2020 10:52 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1257 |
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