Goedhart, L.M. (Louren Matthias) (2014) High-grade sarcoma of the bone: long-term survival and outcome in patients treated in a single center. thesis, Medicine.
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Abstract
Osteosarcoma, Ewing sarcoma and high-grade chondrosarcoma are defined as high-grade sarcomas of the bone. Due to their malignant nature and metastasizing capabilities, radical treatment is deemed essential for survival. The purpose of this study is to analyze and compare long-term outcome and survival for high-grade bone sarcomas treated at University Medical Center Groningen (UMCG). Secondary aims are to investigate functional outcome, quality of life and treatment delay for these patients. The prospectively kept bone tumour registry at UMCG was used to select, 76 patients with osteosarcoma, 32 with Ewing sarcoma and 25 patients suffering from high-grade chondrosarcoma. Clinicopathological characteristics for this series were consistent with literature. Five-year-overall survival for osteosarcoma was 71.3%, decreasing to 38.5% in the case of metastasized tumours (p<0.01). Five-year-overall survival for Ewing sarcoma was 67.2 %. Five-year-overall survival for metastasized Ewing sarcoma was 36.4%. Five-year-overall survival for high-grade chondrosarcoma patients was 71.6%. There were no significant differences in satisfaction and functional outcome between an amputation, prosthetic reconstruction and a grafting procedure. Quality of life, measured using the SF 36 questionnaire, displayed a significant improvement two years after primary therapy in patients after prosthetic reconstruction (76.1%) compared to patients who underwent amputation (35.0%, p=0.04). In conclusion, we believe that this study provides valuable insight in the evaluation of orthopaedic oncological treatment for high-grade bone sarcomas in the Netherlands. As survival rates for high-grade bone sarcomas have not improved over the past decades, further research is essential. This must be aimed towards the development of targeted chemotherapy and reducing doctor-associated delay since metastasis of high-grade bone sarcomas has proven to be disastrous for survival.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Ploegmakers, J.J.W. and Jutte, P.C. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:51 |
| Last Modified: | 25 Jun 2020 10:51 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1253 |
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