Bouwer, A. (Anna) (2018) A Brave Battle Against Hypertension In Patients With Type 2 Diabetes Mellitus. thesis, Medicine.
Full text available on request.Abstract
Background: The combination of type 2 diabetes mellitus (T2DM) and hypertension is unfavourable due to the strongly increased cardiovascular risk. Hypertension is hard to treat in patients with T2DM and often a large number of antihypertensive drugs is required. Patients often fail to reach their blood pressure (BP) targets, with several potential causes. Objective: We examine BP target achievement in patients with T2DM during two-years follow-up. Also, we investigate whether antihypertensive drug therapy (AHT) was altered during follow-up and whether this was associated with BP target achievement. Methods: This study contains a prospective cohort study in 368 patients with T2DM, treated in secondary health care. At baseline, BP was measured and blood and urine samples were collected. Follow-up data was acquired from electronic patient files and pharmacy data. Results: BP target achievement increased from 34 percent of the patients at baseline to 41 percent at two-year follow-up. Regardless of the baseline status, two-third of the patients remained “on target” or “not on target” and one-third changed their status after two-year follow-up. In half of the patients with baseline BP not on target (BP-NOT) an intensification of AHT was made during follow-up, which led to a BP on target (BP-OT) in only a quarter of these patients. Conclusion: BP control in patients with T2DM remains a difficult task, as still less than half of the patients achieved the BP target at two-year follow-up. As only a quarter of the patients with baseline BP-NOT in whom AHT was intensified reached a two-year BP-OT, nonpharmaceutical options should be considered as an important option to treat hypertension in patients with T2DM.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Laverman, Dr. G.D. and Location: and Ziekenhuis Groep Twente and Department: Internal medicine |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:51 |
| Last Modified: | 25 Jun 2020 10:51 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1247 |
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