Schaefer, W. (2012) Cross-reactivity to a novel hair dye precursor Para-phenylenediamine derivative F000175918. thesis, Medicine.
Full text available on request.Abstract
Background: Allergic contact dermatitis to oxidative hair dye products is an important health care issue since the practice of hair dyeing is increasing worldwide and the sensitization rate to the mainly used ingredient, para-phenylenediamine (PPD), is relatively high. Immunologic cross-reactivity to chemicals structurally related to PPD is a common issue and complicates the development of alternative hair dye ingredients. Objective: To determine the rate of cross-reactivity to the newly developed PPD derivative F000175918 by means of patch testing previously PPD-sensitized individuals, using an oxidative hair dye simulation. Methods: Previously PPD-sensitized individuals (+, ++ or +++ reactions at diagnostic patch testing) with a history of allergic contact dermatitis after using hair dye products, were patch tested with PPD derivative F000175918. The oxidative hair dyeing process was simulated using a regular hair dye solution containing the PPD derivative and mixing this in a 1:1 ratio with hydrogen peroxide. Application times were 30, 45 and 60 minutes. The patch-tested skin areas were assessed after 48 and 72 hours. After 7 days an assessment for eventual late reactions was performed. Results: Cross-reactivity to PPD derivative F000175918 occurred in 11 out of 29 of subjects (38%). Depending on the individual PPD sensitization status, extremely sensitized subjects (+++) reacted in 2 out of 3 cases (67%), strongly sensitized subjects (++) in 6 out of 11 cases (55%) and weakly sensitized subjects (+) in 3 out of 15 cases (20%). No late reactions, indicative for active sensitization, occurred in the negative responders. Conclusion: Although PPD derivative F000175918 is a hair dye ingredient with a lower sensitizing potential than the commonly used ones, it is still likely to give cross-reactions in previously PPD-sensitized individuals, especially in those with a high sensitization status (++ and +++).
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Coenraads, prof.dr. P.J. and Department: dermatology, University Medical Center Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:51 |
| Last Modified: | 25 Jun 2020 10:51 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1244 |
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