Mol, G. (Gosse) (2017) Measuring effort of breathing in mechanically ventilated children using surface electromyography of the parasternal muscles and respiratory inductance plethysmography. thesis, Medicine.
Full text available on request.Abstract
Mechanical ventilation is one of the most commonly used interventions within paediatric Intensive Care Units (PICU) all over the world; up to 64% of admitted patients receives mechanical ventilation. Although it is often lifesaving, PICU mortality rates are significantly higher in the mechanically ventilated population due to its serious complications and adverse side effects. This indicates the importance of lung protective ventilation and rapid discontinuation of mechanical ventilation. Despite the important differences between the adult- and the developing respiratory system, most clinical practice concerning paediatric mechanical ventilation is based upon anecdotal experience and studies performed in adults. Hence objective tools and evidence to guide clinicians during initiation, tuning and weaning of mechanical ventilation are often lacking in the paediatric field. Work of breathing (WOB) is an important parameter in ventilatory decision-making. Although it is frequently discussed on PICU’s, actual measurements are seldom performed. This limited clinical application may be explained by the fact that means to measure WOB are not readily available or not easily applied. Several prior studies demonstrated the potential of surface electromyography of the parasternal intercostal muscles (EMGpara) in the matter, but apart from this study, no research specifically focused on the exploration of this feasibility has been conducted. Considering the exploratory nature of this study; non-invasive respiratory inducatance plethysmography (RIP) derived WOB was used to be correlated with EMGpara values. RIP and EMGpara signals were simultaneously registered and analyzed offline. A strong positive correlation of r = 0,651 was found indicating that WOB measurements using EMGpara are feasible and should be the focus of further study.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervised by and Blokpoel R.G.T. and and Kneyber, M.C.J. and Department of Paediatrics, Division of Paediatric Intensive |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:51 |
| Last Modified: | 25 Jun 2020 10:51 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1221 |
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