Western Diet & Inflammatory Bowel Disease

Peters, V. (Vera) (2016) Western Diet & Inflammatory Bowel Disease. thesis, Medicine.

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Abstract

Inflammatory Bowel Disease (IBD), including Ulcerative Colitis (UC) and Crohn’s disease (CD) is a major worldwide issue. It is characterized by chronic, remitting ulcers in the gastrointestinal tract. UC and CD diminish quality of life for over more than 2,5 million people in the Europe alone every day. The etiology of IBD is not completely elucidated yet, however, IBD is expected to be triggered in genetically predisposed individuals by environmental factors, such as diet, microbiome and the immune system. In this scientific clerkship, the contribution of diet to the etiology of IBD is explored further. The habitual diet of 502 IBD cases and 1300 LifeLines control subject has been mapped out using a food frequency questionnaire (FFQ). In the context of prospective prevention of IBD and improving treatment for Ulcerative Colitis and Crohn’s Disease, cases and controls were compared to determine possible risk and protective factors in nutrition. I emphasized on the elements of a Western diet, defined by a higher intake of protein, fat and sugar and a lower consumption of fruit and vegetables. These factors of a Western diet are suggested to constitute a risk for IBD. Results of this study suggests that IBD cases only partly consume a more Western diet; their intake of soft drinks and added sugar to tea is significantly higher and consumption of stir fried vegetables is significantly lower than the intake of these products in control subject. Besides, fat was established to be a risk factor for IBD. However, the mean disease duration of our patient population was over 12 years, therefore, IBD cases had ample time to change their diet based on aggravated symptoms by specific food products and this could have influenced our results. Hence, further research into diet changes and diet shortly after diagnosis should be conducted.

Item Type:	Thesis (Thesis)
Supervisor name:	Dijkstra, Prof. dr G. and Alizadeh, B.Z. and Afdeling MDL & afdeling Epidemiologie and UMCG.
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:39
Last Modified:	25 Jun 2020 10:39
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/114

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