Brat, A. (Aukje) (2014) Complement & Haem. thesis, Medicine.
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Abstract
Earlier research showed that heme as a break down product of erythrocytes is capable of enhancing complement activation. This could play a role in the dysregulation of complement in complement related hemolytic diseases such as atypical hemolytic uremic syndrome. Hypothesis of this research project is that even though heme could cause additional complement activation in serum, this would be an oversimplified view of reality. With a more physiological approach of the pathofysiology, this enhancement will disappear or at least diminish by components not present in serum. Used to prove this hypothesis is a whole blood model, earlier described by Mollnes et al. Experiments in serum do show an enhancement of complement activation. However, when performing these experiments with fresh frozen plasma in stead of serum the significance disappears. By adding heme into the whole blood model results are complex to interpret, but it is certain that the clear enhancement of activation seen in serum is not being seen in a model that has a more physiological approach of the pathophysiology.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Seelen, dr. M.A.J. and Poppelaars, F. and Experimentele Nefrologie and Universitair Medisch Centrum Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:50 |
| Last Modified: | 25 Jun 2020 10:50 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1127 |
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