Kursten, L.J.M. (2017) Changes in muscle mass and body composition during critical illness. thesis, Medicine.
Full text available on request.Abstract
Introduction: Patients, who are admitted to the Intensive Care Unit (ICU) due to critical illness, lose a fair amount of muscle mass during their treatment on the ICU. Muscle wasting leads to functional limitations and disturbances in metabolic processes. This study aims to compare 3 methods to evaluate muscle mass during ICU stay: ultrasound-based quadriceps muscle layer thickness (QMLT), bioimpedance and 24 hour urinary creatinine excretion (UCE). Objective: To assess muscle mass in critically ill patients and to evaluate whether there is a correlation between the ultrasound-based QMLT, bioimpedance en 24h UCE measurements. Methods: A prospective, observational study in patients, who were admitted to the ICU of the MCL. At admission ultrasound-based QMLT and bioimpedance variables were measured and 24 hour urine was collected. Admission data and clinical data (laboratory values, fluid balance, caloric and protein intake) were recorded. Measurements were repeated on day 2, 5, 10 etc. for as long as patients were treated in the ICU. Results: A total of 23 patients were included. There was a 33% decrease of the ultrasound-based QMLT after 10 days of treatment in the ICU. Fat free mass, measured through bioimpedance, decreased with 6% in the first 10 days after admission. In a univariate linear regression analysis, we found a significant correlation between QMLT and FFM after 10 days. 24h UCE could not be analysed because of a non-stable renal function in our patient population. Conclusion: In this small prospective study, we demonstrated a considerable decrease in muscle mass during the first 10 days after ICU admission using bedside ultrasound and bioimpedance measurements.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Buter Mw. Dr. H. and and Koopmans, N. and Intensivists and Location: and Medisch Centrum Leeuwarden, Intensive Care |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1059 |
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