Amersfoort, A. (Anneli) (2012) Juvenile dermatomyositis. thesis, Human Movement Sciences.
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Abstract
Part I : The design of a randomized controlled home-based training program in children and adolescents with juvenile dermatomyositis (including baseline measurements of 10 patients) Part II: Retrospective analysis of the disease course and predicted relative peak oxygen uptake in children and adolescents with juvenile dermaotmyositis: a pilot study Background Juvenile dermatomyositis (JDM) is a rare, often chronic, systemic autoimmune disease of childhood, characterized by inflammation of the microvasculature of the skeletal muscle and skin. Prominent clinical features include significant exercise intolerance, muscle weakness, and fatigue. Exercise training is increasingly utilized as a non-pharmacological intervention in the clinical management of patients with chronic inflammatory conditions. In the current manuscript the rationale and methodology of the randomized controlled training study and preliminary data of the baseline measurements are described. Furthermore, the feasibility of the training program in a few patients will be shown. Methods/Design: In total, 30 children and adolescents with JDM will be included to participate in the randomized controlled trial, however the current manuscript describes and analyses the primary baseline measurements of the first 10 included patients. Intervention consists of an individually tailored 12-weeks home-based exercise training program in which interval training on a treadmill is alternated with strength training during each session. The training program is designed with an individual intensity for each patient. Outcome measures include aerobic exercise capacity, isometric muscle strength, and subjective fatigue. Feasibility of the home-based training program was inventoried in 3 of the first 10 patients, each patient should at least finish 80% of the planned training sessions. Results: All10 patients attained maximal performance during the exercise test. Four out of 10 patients showed normal V02peak values (>82% of predicted), the other 6 patients reached V02peak values between 61-81% of predicted. For maximal strenght of the knee extensors, 6 patients showed a score of >80% of predicted. The other 4 showed a score between 60-80 % of predicted. Five patients had a score >80% of predicted for the maximal strength of the hip flexors. The other 5 scored between 50-70% of predicted. Five patients had a score on the PedsQL Multidimensional Fatigue Scale between 90-120% compared with healthy subjects, the other 5 patients showed a score between 60-90%. All the 3 patients met the feasiblity criteria of finishing 80% of the training sessions. Conclusion: A feasible home-based training program, focused on the major clinical concerns of patients with JDM, is developed. The baseline measurement of the first 10 patients indicates heterogeneous outcomes within the population, which verifies the importance of an individualized approach to exercise and exercise interventions.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Mouton, L.J. MSc and Center for Human Movement Sciences, Faculty of Medical Scien |
| Supervisor name: | Brussel, M. van MSc and Habers, G.E.A. MSc and Child Development and Exercise Center, Wilhelmina Children's and the Netherlands. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1041 |
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