Anakotta, A.M. (2017) Nieuwe modellen voor het vooorspellen van bijwerkingen na radiotherapie in het hoofdhalsgebied. thesis, Medicine.
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Abstract
Background and purpose: radiotherapy in head and neck cancer can lead to acute and late toxicity. The most common forms of late toxicity (persisting after 3 months), are dysphagia and xerostomia. There is a correlation between toxicity and the dose on organs at risk (OARs). Recently, an international guideline on delineating OARs has been published. The goal of this prospective cohort study was to develop new normal tissue complication probality (NTCP) models based on this guideline for predicting the risk of dysphagia and xerostomia. Materials and methods: 221 patients with head and neck cancer were included. Patients were excluded if they were over 70 years old, or had chemotherapy and/or surgery. Dysphagia and xerostomia were scored according to the common terminology criteria for adverse events (CTCAE). The models were developed using a multivariate analysis with backward selection. Results: in the model for dysphagia the mean dose to the mucosa (oral cavity + pharyngeal constrictor muscle) was the best predictor. This model had a p-value of 0.001 and a AUC of 0.77. The best predictor for xerostomia was the mean dose to the parotid glands. The p-value for this model was 0.001 with an AUC of 0.71. Conclusion: we developed new NTCP models with a good performance for dysphagia and xerostomia. These models can be used for optimizing treatment plans and selection of treatment modality.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Begeleiders: and Langendijk, Prof. dr. J.A. and Steenbakkers, Dr. R.J.H.M. and Afdeling Radiotherapie, Universitair Medisch Centrum Groning and Rijksuniversiteit Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1031 |
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