Stoffers, R.H. (Rutger) (2016) Assessment of Myocardial Injury after Reperfused Infarction by T1ρ MRI. thesis, Medicine.
![[img]](https://umcg.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
StoffersRH.pdf Restricted to Registered users only Download (19MB) |
Abstract
Purpose - In many patients, the golden standard for imaging of myocardial infarction (MI), late gadolinium enhanced (LGE) MRI, is contra-indicated. T1ρ MRI is an emerging method for endogenous MRI contrast imaging of MI, but the evolution of it and other endogenous contrast quantitative methods (T2, T1) in the first month after reperfused MI is uncertain. We conducted a study of reperfused MI in swine to serially monitor T1ρ, T2 and T1 relaxation maps at baseline, 1 week and 4 weeks post-MI and correlated these results with LGE MRI, histopathology, and high spatial resolution ex vivo MRI. Methods - 16 Yorkshire swine underwent 90 minutes of occlusion of the circumflex artery and reperfusion. T1ρ, T2 and native T1 MRI maps and LGE MRI data were collected at 1 week (n=16) and 4 week (n=11). Ex vivo MRI, thin-slice optical tissue scanning, and histology were performed at each terminal time point. Semi-automatic ‘Full Width Half Max’ (FWHM) thresholding was used to assess scar size and scar transmurality in T1ρ, T2, T1 and LGE MRI. In vivo MRI was spatially correlated to ex vivo MRI and histopathology Results - Infarct T1ρ increased 74.6 (1 week) and 73.4 ms (4 weeks) and T2 increased 51.6 ms (1 week) and 59.2 ms (4 weeks). In vivo T1ρ relaxation time was longer than T2 in both remote and infarcted tissue (p < 0.01). T1ρ and LGE scar size and transmurality were highly correlated 1 week and 4 week post-MI (p < 0.05). Conclusion - T1ρ relaxation times were highly correlated with left ventricle (LV) pathology alterations at 1 and 4 weeks post-MI and therefore it may be a useful method for non-contrast enhanced imaging of infarction.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty Supervisor: and Kallenberg, Prof. dr C.G.M. |
| Supervisor name: | External Supervisor: and Witschey, W.R.T. Assistant Profesor and The University of Pennsylvania, Perelman School and Of Medicine, Department of Radiology and Philadelphia, Pennsylvania and And and The Gorman Cardiovascular Research Group |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1023 |
Actions (login required)
 |
View Item |