Vries, L. de (Linda) (2018) Hypernatriëmie bij patiënten op de Intensive Care. thesis, Medicine.
Full text available on request.Abstract
Introduction: ICU-acquired hypernatremia, (IAH, serum sodiumconcentration (s[Na]) ≥ 143 mmol/l) is associated with a higher morbidity and mortality. It is mainly considered iatrogenic, induced by sodium intake and water deficit. The main goal of the study is to investigate if there is a difference in sodium intake and fluid balance between the IAH(-) and IAH(+) groups and to explore other factors. Methods: Prospective observational cohortstudy in the Intensive Care Unit (ICU) in Medisch Centrum Leeuwarden. Included patients were admitted in an acute setting, were at least 18 years old and had a ICU length of stay of at least 48 hours. Results: the sodium intake within the first 24 hours of ICU admission was 8,4 [4,8-12,9] grams in the IAH(-) group and 7,0 [4,0-13,0] grams in the IAH(+) group, p=0,649. Between 24 and 96 hours this was 12,0 [10,2-14,3] grams in the IAH(-) group versus 15,9 [7,4-19,3] grams in the IAH(+) group, p=0,377). The median fluid balance within the first 24 hours was 1,2 [0,1-2,4] liters in the IAH(-) group versus 1,2 [0,6-2,0] liters in IAH(+) group. Between 24 and 96 hours this was 0,9 [-0,3-1,9] liters in the IAH(-) group and 1,7 [-0,7-3,3] liters in the IAH(+) group. Conclusion: Despite the current opinion, IAH is not explained by sodium intake of fluid balance. This makes IAH not a primary iatrogenic complication. A renal problem of the third compartment could play a role in the development of IAH.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Boerma, dhr. dr. C.H. and Locatie: Intensive Care, Medisch Centrum Leeuwarden |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1022 |
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