Ruijne, R.E. (Roos Eva) (2012) The effect of delayed cord clamping on haematological status in low birth weight infants: an interim analysis of an ongoing randomised controlled trial in South Africa. thesis, Medicine.
Full text available on request.Abstract
Background: Delayed cord clamping (DCC) is a cost-effective and natural solution to prevent anaemia in infancy. The intervention has not been studied in low birth weight infants in resource-poor settings. Objective: To evaluate the haematological effects of delayed and early cord clamping (ECC) in low birth weight infants Methods: We report the interim results of a randomised controlled trial. Infants born from mothers with an intrapartum symphysal fundal height (ISFH) ≤ 34 cm were eligible for inclusion. So far we have included 57 infants. Infant blood samples were taken from the umbilical cord immediately after birth, after 24 hours and two months by venepuncture. Primary outcomes of the trial are infant haemoglobin levels and iron status at two months of age. As the follow-up data at two months were still incomplete during this interim-analysis, we focussed on the side effects within the first 24 hours after delivery including hyperbilirubinemia and polycythaemia. Results: After 4 months of recruitment the inclusion rate was satisfying. We included 11% more than expected. 35% of the included infants actually had a low birth weight (< 2500 g), approximately ⅓ of the total group already returned for the two months follow-up.7 infants were lost to follow-up so far. In the group that was subjected to ECC haematocrit on second day post-partum was 0.47 ± 0.06 compared to 0.48 ± 0.08 in the DCC group. The proportion of children that required phototherapy on the first day after birth was 12 %. Conclusion: Polycythaemia did not occur. There was no difference in occurrence in hyperbilirubinemia between the two groups. We decided that there were no reasons to end this study prematurely. Recruitment of study participants will continue till we have included 102 infants.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Rheenen, Dr. Patrick van |
| Supervisor name: | External supervisor: and Tiemersma, Drs. Sybrich and Location: Stanger hospital, Corner of King Shaka and Patters and Department: paediatrics and gynaecology |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:39 |
| Last Modified: | 25 Jun 2020 10:39 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/102 |
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